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BrainGate™ Co. has a strong and diverse intellectual property portfolio, including exclusive rights to key patents surrounding neural interfaces and their use to control computers, prosthesis, and other devices. BrainGate™ Co. also has rights to intellectual property from related research projects conducted at leading Universities, including Brown, Emory, Columbia and MIT. 

In addition to its unique patent portfolio, BrainGate™ Co. is also focused on the analysis and interpretation of neural recordings through software and neural network innovation.  In the future, this capability could allow for the recording of electrical data for future analysis, a massive advantage for medical practitioners to study patient’s everyday patterns to determine medical treatment. For example, a potential use of this feature would be for a neurologist to study seizure patterns in a patient with epilepsy.

The following table includes a sample of our current patent portfolio.  In addition to these patents, BrainGate™ Co. owns various trademarks including Bionics®, Neuroport® and Cerebus®.  For more information on licensing our intellectual property, please contact us.



 

US20060206167A1 


US26206167A1?crop=1&PAGE=2
(p2/29)

Multi-device patient ambulation system
    Various embodiments of an ambulation and movement assist system are disclosed. For example, an ambulation system for a patient may comprise an exoskeleton device attached to the patient, an FES device at least partially implanted in the patient, and a biological interface apparatus. The biological interface apparatus comprises a sensor having a plurality of electrodes for detecting multicellular signals, a processing unit configured to receive the multicellular signals from the sensor, process the multicellular signals to produce a processed signal, and transmit the processed signal to a controlled device. At least one of the exoskeleton device and the FES device is the controlled device of the biological interface apparatus.

US20060195042A1 


US26195042A1?crop=1&PAGE=2
(p2/37)

Biological interface system with thresholded configuration
    A system and method for a biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system further includes an automated configuration routine that is used to set or modify the value of one or more system configuration parameters.

US20060189901A1 


US26189901A1?crop=1&PAGE=2
(p2/25)

Biological interface system with surrogate controlled device
    Various embodiments of a biological interface system and related methods are disclosed. The system may include a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient, and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device. The system further includes a first controlled device configured to receive the processed signal, and a second controlled device configured to receive the processed signal. The first controlled device may provide feedback to the patient to improve control of the second controlled device.

US20060189900A1 


US26189900A1?crop=1&PAGE=2
(p2/36)

Biological interface system with automated configuration
    A system and method for a biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system further includes an automated configuration routine that is used to set or modify the value of one or more system configuration parameters.

US20060189899A1 


US26189899A1?crop=1&PAGE=2
(p2/38)

Joint movement apparatus
    Systems, methods and devices for restoring or enhancing one or more motor functions of a patient are disclosed. The system comprises a biological interface apparatus and a joint movement device such as an exoskeleton device or FES device. The biological interface apparatus includes a sensor that detects the multicellular signals and a processing unit for producing a control signal based on the multicellular signals. Data from the joint movement device is transmitted to the processing unit for determining a value of a configuration parameter of the system. Also disclosed is a joint movement device including a flexible structure for applying force to one or more patient joints, and controlled cables that produce the forces required.

US20060173259A1 


US26173259A1?crop=1&PAGE=2
(p2/40)

Biological interface system
    A system and method for an improved biological interface system that processes multicellular signals of a patient and controls one or more devices is disclosed. The system includes a sensor that detects the multicellular signals and a processing unit for producing the control signal based on the multicellular signals. The system may include improved communication, self-diagnostics, and surgical insertion tools.

US20060167564A1 


US26167564A1?crop=1&PAGE=2
(p2/37)

Limb and digit movement system
    Systems, methods and devices for restoring or enhancing one or more motor functions of a patient are disclosed. The system comprises a biological interface apparatus and a joint movement device such as an exoskeleton device or FES device. The biological interface apparatus includes a sensor that detects the multicellular signals and a processing unit for producing a control signal based on the multicellular signals. Data from the joint movement device is transmitted to the processing unit for determining a value of a configuration parameter of the system. Also disclosed is a joint movement device including a flexible structure for applying force to one or more patient joints, and controlled cables that produce the forces required.

US20060167530A1 


US26167530A1?crop=1&PAGE=2
(p2/33)

Patient training routine for biological interface system
    Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to generate one or more system configuration parameters that are used by the processing unit to produce the processed signal.

US20060167371A1 


US26167371A1?crop=1&PAGE=2
(p2/28)

Biological interface system with patient training apparatus
    Various embodiments of a biological interface system and related methods are disclosed. The system may include a sensor having a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient, and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system may also include a patient training apparatus configured to receive a patient training signal that causes the patient training apparatus to controllably move one or more joints of the patient. The system may be configured to perform an integrated patient training routine to produce the patient training signal, to store a set of multicellular signal data detected during a movement of the one or more joints, and to correlate the set of multicellular signal data to a second set of data related to the movement of the one or more joints.

US20060149338A1 


US26149338A1?crop=1&PAGE=2
(p2/32)

Neurally controlled patient ambulation system
    Various embodiments of an ambulation system and a movement assist system are disclosed. For example, an ambulation system for a patient may comprise a biological interface apparatus and an ambulation assist apparatus. The biological interface apparatus may comprise a sensor having a plurality of electrodes for detecting multicellular signals, a processing unit configured to receive the multicellular signals from the sensor, process the multicellular signals to produce a processed signal, and transmit the processed signal to a controlled device. The ambulation assist apparatus may comprise a rigid structure configured to provide support between a portion of the patient's body and a surface. Data may be transferred from the ambulation assist apparatus to the biological interface apparatus.

US20060058627A1 


US26058627A1?crop=1&PAGE=2
(p2/27)

Biological interface systems with wireless connection and related methods
    Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor, to process the multicellular signals to produce processed signals, and to transmit the processed signals. The system may also include a controlled device configured to receive the processed signals from the processing unit. The processing unit may include a processing unit first portion and a processing unit second portion, where the processing unit first portion is implanted under the scalp on the skull of the patient, and the processing unit second portion is placed above the scalp of the patient at a location proximal to the processing unit first portion.

US20060049957A1 


US26049957A1?crop=1&PAGE=2
(p2/28)

Biological interface systems with controlled device selector and related methods
    Various embodiments of a biological interface system and their related methods are disclosed. A biological interface system may include a sensor including a plurality of electrodes configured to detect multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and to process the multicellular signals to produce processed signals. The system may also include a plurality of controlled devices each configured to receive the processed signals. The plurality of controlled devices include at least a first controlled device and a second controlled device. The system may include a selector module usable by an operator and being configured to select which of the first and second controlled devices is to be controlled by the processed signals.

US20050283203A1 


US25283203A1?crop=1&PAGE=2
(p2/21)

Transcutaneous implant
    Devices, systems and methods are disclosed for a neural access device that includes an implant which transcutaneously exits the skin of a patient and provides transport of signals between a sensor implanted in a patient and an external device. The transcutaneous implant has integrated features to provide reduced risk of injury due to mechanical forces as well as electrostatic discharge energy applied to the external portion of the device. Transcutaneous devices which provide wireless communication between a sensor and an external device are also disclosed.

US20050273890A1 


US25273890A1?crop=1&PAGE=2
(p2/21)

Neural interface system and method for neural control of multiple devices
    A system and method for a neural interface system with a unique identification code includes a sensor including a plurality of electrodes to detect multicellular signals, an processing unit to process the signals from the sensor into a suitable control signal for a controllable device such as a computer or prosthetic limb. The unique identification code is embedded in one or more discrete components of the system. Internal and external system checks for compatibility and methods of ensuring safe and effective performance of a system with detachable components are also disclosed.

US20050267597A1 


US25267597A1?crop=1&PAGE=2
(p2/21)

Neural interface system with embedded id
    A system and method for a neural interface system with a unique identification code includes a sensor including a plurality of electrodes to detect multicellular signals, an processing unit to process the signals from the sensor into a suitable control signal for a controllable device such as a computer or prosthetic limb. The unique identification code is embedded in one or more discrete components of the system. Internal and external system checks for compatibility and methods of ensuring safe and effective performance of a system with detachable components are also disclosed.

US20050203366A1 


US25203366A1?crop=1&PAGE=2
(p2/27)

Neurological event monitoring and therapy systems and related methods
    Systems and methods for detecting, monitoring, and/or treating neurological events based on, for example, electrical signals generated from the patient's body are disclosed. Various embodiments of the invention include a system for predicting occurrence of a neurological event in a patient's body. The system may include an implant configured to be placed in the body and detect signals indicative of an activity that precedes the neurological event, and a processing unit configured to process the detected signals so as to predict the neurological event prior to the occurrence.

US20050143589A1 


US25143589A1?crop=1&PAGE=2
(p2/14)

Calibration systems and methods for neural interface devices
    A system and method for a neural interface system with integral calibration elements may include a sensor including a plurality of electrodes to detect multicellular signals, an interface to process the signals from the sensor into a suitable control signal for a controllable device, such as a computer or prosthetic limb, and an integrated calibration routine to efficiently create calibration output parameters used to generate the control signal. A graphical user interface may be used to make various portions of the calibration and signal processing configuration more efficient and effective.

US20050113744A1 


US25113744A1?crop=1&PAGE=2
(p2/25)

Agent delivery systems and related methods under control of biological electrical signals
    Systems and methods are disclosed for detecting neural, biological, or other electrical signals generated within a patient's body and processing those signals to generate a control signal that may control the delivery of a biologic, therapeutic, or other agent, such as a drug. Embodiments include a system having a sensor implanted in a patient's brain to detect neural signals used to control delivery of a drug to the patient. The system may also control an internal and/or external device, such as a prosthetic limb, and control delivery of a drug to increase the performance of the system and/or the controlled device.

US20040249302A1 

US24249302A1?crop=1

Methods and systems for processing of brain signals
    System and methods consistent with the present invention decode brain signals. The system includes a receiver for receiving an input signal representing multiple individual neuron signals, and a frequency filter for separating the multiple neuron signals from the received input neural signal. A rectifier full wave rectifies the filtered neural signal and an integrator integrates the rectified neural signal to obtain an envelope of the rectified neural signal. As a result of this processing, sample values of the neural signal envelope represent neurological activity.

US20040015211A1 


US24015211A1?crop=1&PAGES=27

Optically-connected implants and related systems and methods of use
    According to embodiments of the invention, one or more implants in a body may be connected with optical fibers for transmitting data and/or power to or from the implants. Aspects of the invention related to various embodiments of the actual implant as well as to various embodiments for connecting optical fibers to the implants.

US7280870 


US07280870__?crop=1&PAGE=5
(p5/28)

Optically-connected implants and related systems and methods of use
    According to embodiments of the invention, one or more implants in a body may be connected with optical fibers for transmitting data and/or power to or from the implants. Aspects of the invention related to various embodiments of the actual implant as well as to various embodiments for connecting optical fibers to the implants.

US20070106143A1 


US27106143A1?crop=1&PAGES=43&PAGE=2
(p2/43)

Electrode arrays and related methods
    Various embodiments of an electrode array system and related methods are disclosed. The system may include a probe assembly having a plurality of probes configured to penetrate tissue of a patient and a guide assembly having a plurality of guiding channels. Each of the guiding channels may be configured to guide one or more of the plurality of probes to a desired tissue site. Some embodiments of an electrode array may include a housing and a plurality of probes extending from the housing. At least one of the plurality of probes may be individually deployable from the housing.

US20070032738A1 


US27032738A1?crop=1&PAGE=2
(p2/27)

Adaptive patient training routine for biological interface system
    Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to generate one or more system configuration parameters that are used by the processing unit to produce the processed signal.

US20060253166A1 


US26253166A1?crop=1&PAGE=2
(p2/27)

Patient training routine for biological interface system
    
Various embodiments of a biological interface system and related methods are disclosed. The system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient and a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal. The processing unit may be configured to transmit the processed signal to a controlled device that is configured to receive the processed signal. The system is configured to perform an integrated patient training routine to provide a time varying stimulus to the patient and to generate one or more system configuration parameters used by the processing unit to produce the processed signal.

US20060241356A1 


US26241356A1?crop=1&PAGE=2
(p2/27)

Biological interface system with gated control signal
    
Various embodiments of a biological interface system and related methods are disclosed. The biological interface system may comprise a sensor comprising a plurality of electrodes for detecting multicellular signals emanating from one or more living cells of a patient, a processing unit configured to receive the multicellular signals from the sensor and process the multicellular signals to produce a processed signal, and a signal gate configured to receive the processed signal from the processing unit and an alternative signal generated by the system, the signal gate being configured to transmit a control signal to a controlled device based on either the processed signal or the alternative signal. A monitoring unit may receive system data and process the system data to produce a system status signal. The system status signal may be used to determine which of the processed signal and the alternative signal is to be used as the control signal.

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Our company's core BrainGate™ technology is available through engineering and manufacturing partners:
Bionic®, Neural array microchips used in our core technology.
NeuroPort® system for human clinical trials.
Cerebus® system used for research and testing.
Contact us for more information and pricing
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